Transcription factors with Perturb-seq knockdown data for ENSG00000289272. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289272 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289272, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:43,995,542–43,996,864 | 232.0 kb | Distal (>10kb) Multiome | 909 | |
| chr2:44,044,245–44,044,695 | 183.8 kb | Distal (>10kb) Multiome | 537 | |
| chr2:44,086,758–44,087,671 | 140.9 kb | Distal (>10kb) Multiome | 648 | |
| chr2:44,167,415–44,169,762 | 59.6 kb | Distal (>10kb) Multiome | 1028 | |
| chr2:44,361,086–44,362,690 | 133.7 kb | Distal (>10kb) Multiome | 985 |
Genomic view of the ENSG00000289272 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.