Transcription factors with Perturb-seq knockdown data for ENSG00000289262. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289262 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289262, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:131,061,961–131,064,084 | 231.1 kb | Distal (>10kb) Multiome | 841 | |
| chr6:131,135,132–131,136,378 | 158.8 kb | Distal (>10kb) Multiome | 830 | |
| chr6:131,293,145–131,294,684 | at TSS | At TSS | 159 | |
| chr6:131,294,899–131,295,742 | 964 bp | At TSS Multiome | 115 | |
| chr6:131,297,061–131,297,314 | 2.6 kb | Proximal (<10kb) | 3 | |
| chr6:131,300,751–131,301,064 | 6.3 kb | Proximal (<10kb) | 7 |
Genomic view of the ENSG00000289262 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.