Transcription factors with Perturb-seq knockdown data for ENSG00000289153. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289153 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289153, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:115,783,895–115,785,146 | 7.4 kb | Proximal (<10kb) | 883 | |
| chr3:115,790,776–115,791,102 | 1.4 kb | Proximal (<10kb) | 369 | |
| chr3:115,791,339–115,792,577 | at TSS | At TSS | 369 | |
| chr3:115,792,697–115,793,012 | 194 bp | At TSS | 149 | |
| chr3:115,794,729–115,795,216 | 2.2 kb | Proximal (<10kb) | 4 | |
| chr3:115,797,394–115,797,617 | 4.9 kb | Proximal (<10kb) | 0 |
Genomic view of the ENSG00000289153 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.