Transcription factors with Perturb-seq knockdown data for ENSG00000289142. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289142 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289142, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:220,874,301–220,874,673 | 4.5 kb | Proximal (<10kb) | 178 | |
| chr1:220,876,876–220,877,994 | 1.2 kb | Proximal (<10kb) | 210 | |
| chr1:220,878,403–220,880,339 | at TSS | At TSS | 527 | |
| chr1:220,880,930–220,881,583 | 1.7 kb | Proximal (<10kb) | 140 | |
| chr1:220,881,960–220,882,952 | 2.8 kb | Proximal (<10kb) | 181 | |
| chr1:220,883,958–220,885,196 | 4.8 kb | Proximal (<10kb) | 155 | |
| chr1:220,887,128–220,888,689 | 7.9 kb | Proximal (<10kb) | 128 |
Genomic view of the ENSG00000289142 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.