Transcription factors with Perturb-seq knockdown data for ENSG00000289125. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289125 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289125, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:25,971,214–25,971,968 | 5.5 kb | Proximal (<10kb) | 77 | |
| chr13:25,977,016–25,977,600 | at TSS | At TSS | 163 | |
| chr13:25,977,740–25,978,960 | 236 bp | At TSS | 191 | |
| chr13:25,979,350–25,979,890 | 1.8 kb | Proximal (<10kb) | 22 | |
| chr13:25,980,132–25,980,600 | 2.6 kb | Proximal (<10kb) | 61 |
Genomic view of the ENSG00000289125 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.