Transcription factors with Perturb-seq knockdown data for ENSG00000289113. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289113 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289113, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:208,406,386–208,407,453 | 892.8 kb | Distal (>10kb) Multiome HiCAR | 324 | |
| chr2:209,208,033–209,210,222 | 90.3 kb | Distal (>10kb) Multiome | 321 | |
| chr2:209,298,652–209,299,936 | 70 bp | At TSS Multiome | 105 | |
| chr2:209,300,735–209,301,261 | 1.0 kb | Proximal (<10kb) | 55 | |
| chr2:209,304,507–209,304,966 | 4.8 kb | Proximal (<10kb) | 43 | |
| chr2:209,305,077–209,308,685 | 8.0 kb | Proximal (<10kb) Multiome | 373 | |
| chr2:209,423,435–209,424,894 | 124.3 kb | Distal (>10kb) Multiome | 597 |
Genomic view of the ENSG00000289113 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.