Transcription factors with Perturb-seq knockdown data for ENSG00000289109. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289109 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289109, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:23,181,578–23,182,460 | 292.7 kb | Distal (>10kb) Multiome | 935 | |
| chr7:23,205,915–23,206,590 | 268.4 kb | Distal (>10kb) Multiome | 154 | |
| chr7:23,247,362–23,248,065 | 226.9 kb | Distal (>10kb) Multiome | 202 | |
| chr7:23,299,105–23,299,994 | 175.3 kb | Distal (>10kb) Multiome | 852 | |
| chr7:23,465,333–23,465,840 | 9.1 kb | Proximal (<10kb) Multiome | 410 | |
| chr7:23,467,898–23,468,049 | 6.6 kb | Proximal (<10kb) | 281 | |
| chr7:23,468,151–23,470,057 | 4.6 kb | Proximal (<10kb) | 623 | |
| chr7:23,470,190–23,471,917 | 4.0 kb | Proximal (<10kb) Multiome | 922 | |
| chr7:23,473,588–23,475,134 | 171 bp | At TSS Multiome | 996 | |
| chr7:23,531,132–23,532,637 | 57.4 kb | Distal (>10kb) Multiome | 1024 | |
| chr7:23,596,997–23,598,169 | 122.8 kb | Distal (>10kb) Multiome | 879 | |
| chr7:23,679,780–23,681,279 | 206.4 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the ENSG00000289109 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.