Transcription factors with Perturb-seq knockdown data for ENSG00000288895. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288895 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288895, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:174,440,738–174,441,965 | 1885.9 kb | Distal (>10kb) Multiome HiCAR | 738 | |
| chr3:176,320,980–176,322,548 | 4.5 kb | Proximal (<10kb) | 121 | |
| chr3:176,324,095–176,324,543 | 2.5 kb | Proximal (<10kb) | 6 | |
| chr3:176,324,739–176,325,202 | 1.9 kb | Proximal (<10kb) | 7 | |
| chr3:176,325,319–176,326,142 | 923 bp | At TSS | 95 | |
| chr3:176,326,301–176,327,600 | 54 bp | At TSS Multiome | 176 | |
| chr3:176,361,854–176,362,986 | 35.3 kb | Distal (>10kb) Multiome | 182 | |
| chr3:176,505,824–176,506,573 | 179.0 kb | Distal (>10kb) Multiome | 217 | |
| chr3:178,211,520–178,212,768 | 1885.1 kb | Distal (>10kb) Multiome HiCAR | 96 |
Genomic view of the ENSG00000288895 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.