Transcription factors with Perturb-seq knockdown data for ENSG00000288879. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288879 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288879, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:34,227,295–34,227,501 | 9.2 kb | Proximal (<10kb) | 156 | |
| chr6:34,234,536–34,237,980 | at TSS | At TSS | 1100 | |
| chr6:34,238,090–34,238,354 | 1.3 kb | Proximal (<10kb) | 881 | |
| chr6:34,246,464–34,249,721 | 9.7 kb | Proximal (<10kb) | 1030 |
Genomic view of the ENSG00000288879 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.