Transcription factors with Perturb-seq knockdown data for ENSG00000288871. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288871 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288871, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:50,244,340–50,245,635 | at TSS | At TSS | 868 | |
| chr22:50,247,828–50,248,046 | 3.2 kb | Proximal (<10kb) | 154 | |
| chr22:50,250,480–50,251,917 | 5.8 kb | Proximal (<10kb) | 683 | |
| chr22:50,252,224–50,252,418 | 7.6 kb | Proximal (<10kb) | 229 |
Genomic view of the ENSG00000288871 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.