Transcription factors with Perturb-seq knockdown data for ENSG00000288856. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288856 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288856, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:40,008,825–40,009,356 | 162.8 kb | Distal (>10kb) Multiome | 152 | |
| chrX:40,014,248–40,015,286 | 157.0 kb | Distal (>10kb) Multiome | 617 | |
| chrX:40,097,449–40,098,830 | 74.0 kb | Distal (>10kb) Multiome | 528 | |
| chrX:40,153,521–40,154,571 | 17.8 kb | Distal (>10kb) Multiome | 496 | |
| chrX:40,157,251–40,157,705 | 14.4 kb | Distal (>10kb) Multiome | 143 | |
| chrX:40,158,041–40,158,745 | 13.5 kb | Distal (>10kb) Multiome | 405 | |
| chrX:40,167,909–40,168,096 | 3.8 kb | Proximal (<10kb) | 153 | |
| chrX:40,169,190–40,170,089 | 2.3 kb | Proximal (<10kb) Multiome | 620 | |
| chrX:40,175,263–40,175,865 | 3.3 kb | Proximal (<10kb) | 618 | |
| chrX:40,176,539–40,176,911 | 4.6 kb | Proximal (<10kb) | 414 | |
| chrX:40,474,058–40,474,871 | 302.4 kb | Distal (>10kb) Multiome HiCAR | 312 |
Genomic view of the ENSG00000288856 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.