Transcription factors with Perturb-seq knockdown data for ENSG00000288823. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288823 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288823, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,771,782–73,773,237 | 8.8 kb | Proximal (<10kb) | 918 | |
| chr10:73,781,688–73,782,352 | at TSS | At TSS | 721 | |
| chr10:73,785,180–73,785,869 | 3.2 kb | Proximal (<10kb) | 745 | |
| chr10:73,786,078–73,786,365 | 4.1 kb | Proximal (<10kb) | 368 |
Genomic view of the ENSG00000288823 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.