Transcription factors with Perturb-seq knockdown data for ENSG00000288808. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288808 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288808, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:37,095,160–37,095,408 | 6.8 kb | Proximal (<10kb) | 97 | |
| chr15:37,097,156–37,097,549 | 4.6 kb | Proximal (<10kb) | 120 | |
| chr15:37,098,929–37,099,154 | 3.0 kb | Proximal (<10kb) | 271 | |
| chr15:37,100,244–37,101,061 | 1.1 kb | Proximal (<10kb) | 660 | |
| chr15:37,101,201–37,102,291 | at TSS | At TSS | 671 | |
| chr15:37,106,502–37,106,635 | 4.3 kb | Proximal (<10kb) | 101 | |
| chr15:37,106,747–37,106,943 | 4.5 kb | Proximal (<10kb) | 88 | |
| chr15:37,107,111–37,107,542 | 4.9 kb | Proximal (<10kb) | 70 | |
| chr15:37,110,814–37,111,049 | 8.6 kb | Proximal (<10kb) | 245 |
Genomic view of the ENSG00000288808 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.