Transcription factors with Perturb-seq knockdown data for ENSG00000288789. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288789 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288789, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:94,643,177–94,643,647 | 6.7 kb | Proximal (<10kb) | 75 | |
| chr11:94,647,835–94,648,344 | 2.0 kb | Proximal (<10kb) | 80 | |
| chr11:94,649,720–94,650,679 | at TSS | At TSS | 129 | |
| chr11:94,656,851–94,657,401 | 6.5 kb | Proximal (<10kb) | 99 | |
| chr11:94,658,822–94,659,248 | 8.5 kb | Proximal (<10kb) | 28 |
Genomic view of the ENSG00000288789 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.