Transcription factors with Perturb-seq knockdown data for ENSG00000288774. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288774 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288774, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:147,864,777–147,865,131 | 9.2 kb | Proximal (<10kb) | 3 | |
| chr5:147,868,433–147,870,551 | 3.8 kb | Proximal (<10kb) | 335 | |
| chr5:147,872,851–147,873,158 | 1.2 kb | Proximal (<10kb) | 11 | |
| chr5:147,873,930–147,875,597 | at TSS | At TSS | 295 | |
| chr5:147,882,791–147,883,143 | 8.5 kb | Proximal (<10kb) | 31 |
Genomic view of the ENSG00000288774 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.