Transcription factors with Perturb-seq knockdown data for ENSG00000288762. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288762 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288762, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:76,761,176–76,762,367 | 187.0 kb | Distal (>10kb) Multiome | 486 | |
| chr14:76,784,691–76,785,144 | 163.7 kb | Distal (>10kb) Multiome | 318 | |
| chr14:76,812,161–76,813,291 | 135.9 kb | Distal (>10kb) Multiome | 878 | |
| chr14:76,913,323–76,913,886 | 35.1 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr14:76,924,332–76,925,072 | 24.0 kb | Distal (>10kb) Multiome HiCAR | 256 | |
| chr14:76,947,024–76,947,904 | 1.2 kb | Proximal (<10kb) Multiome | 690 | |
| chr14:76,955,827–76,957,395 | 7.8 kb | Proximal (<10kb) Multiome HiCAR | 873 | |
| chr14:76,957,542–76,957,973 | 8.8 kb | Proximal (<10kb) | 199 | |
| chr14:76,961,044–76,962,678 | 13.2 kb | Distal (>10kb) Multiome HiCAR | 848 | |
| chr14:76,968,574–76,969,080 | 20.2 kb | Distal (>10kb) Multiome HiCAR | 311 | |
| chr14:77,024,027–77,024,710 | 75.6 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr14:77,025,547–77,029,182 | 80.0 kb | Distal (>10kb) Multiome HiCAR | 996 | |
| chr14:77,032,573–77,034,628 | 84.5 kb | Distal (>10kb) Multiome HiCAR | 917 | |
| chr14:77,040,063–77,040,913 | 91.8 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr14:77,088,297–77,088,792 | 139.8 kb | Distal (>10kb) Multiome | 234 | |
| chr14:77,097,312–77,099,236 | 149.4 kb | Distal (>10kb) Multiome HiCAR | 948 | |
| chr14:77,124,505–77,125,759 | 176.3 kb | Distal (>10kb) Multiome | 289 | |
| chr14:77,139,459–77,142,559 | 191.1 kb | Distal (>10kb) Multiome | 507 | |
| chr14:77,181,185–77,182,207 | 233.0 kb | Distal (>10kb) Multiome | 485 |
Genomic view of the ENSG00000288762 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.