Transcription factors with Perturb-seq knockdown data for ENSG00000288755. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288755 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288755, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:3,197,197–3,197,909 | 588.0 kb | Distal (>10kb) Multiome HiCAR | 553 | |
| chr10:3,668,413–3,668,963 | 116.8 kb | Distal (>10kb) Multiome | 431 | |
| chr10:3,775,491–3,776,525 | 9.5 kb | Proximal (<10kb) Multiome | 502 | |
| chr10:3,781,501–3,781,681 | 3.9 kb | Proximal (<10kb) | 264 | |
| chr10:3,783,425–3,783,624 | 1.9 kb | Proximal (<10kb) | 371 | |
| chr10:3,783,759–3,784,438 | 1.6 kb | Proximal (<10kb) Multiome | 584 | |
| chr10:3,784,603–3,787,605 | 1.3 kb | Proximal (<10kb) Multiome | 1182 | |
| chr10:3,887,108–3,888,567 | 102.7 kb | Distal (>10kb) Multiome | 430 | |
| chr10:3,890,598–3,891,428 | 105.5 kb | Distal (>10kb) Multiome | 408 | |
| chr10:4,007,209–4,008,542 | 222.4 kb | Distal (>10kb) Multiome | 100 | |
| chr10:4,083,313–4,084,049 | 298.1 kb | Distal (>10kb) Multiome | 160 | |
| chr10:4,130,115–4,131,122 | 345.0 kb | Distal (>10kb) Multiome HiCAR | 258 |
Genomic view of the ENSG00000288755 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.