Transcription factors with Perturb-seq knockdown data for ENSG00000288752. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288752 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288752, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:97,761,283–97,761,890 | 284.0 kb | Distal (>10kb) Multiome | 88 | |
| chr8:97,774,820–97,776,789 | 269.8 kb | Distal (>10kb) Multiome | 1013 | |
| chr8:97,781,999–97,784,345 | 262.0 kb | Distal (>10kb) Multiome | 298 | |
| chr8:97,868,488–97,870,075 | 176.2 kb | Distal (>10kb) Multiome HiCAR | 498 | |
| chr8:98,011,075–98,011,541 | 34.5 kb | Distal (>10kb) Multiome | 178 | |
| chr8:98,037,042–98,037,391 | 8.3 kb | Proximal (<10kb) | 138 | |
| chr8:98,045,232–98,046,414 | 20 bp | At TSS Multiome | 829 | |
| chr8:98,064,246–98,065,195 | 19.1 kb | Distal (>10kb) Multiome | 385 | |
| chr8:98,116,581–98,117,836 | 71.6 kb | Distal (>10kb) Multiome | 829 | |
| chr8:98,169,855–98,170,713 | 124.6 kb | Distal (>10kb) Multiome | 369 | |
| chr8:98,293,197–98,294,622 | 248.4 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the ENSG00000288752 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.