Transcription factors with Perturb-seq knockdown data for ENSG00000288735. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288735 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288735, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:29,314,757–29,315,219 | 5.0 kb | Proximal (<10kb) | 219 | |
| chr8:29,315,351–29,315,539 | 4.7 kb | Proximal (<10kb) | 91 | |
| chr8:29,315,642–29,315,835 | 4.4 kb | Proximal (<10kb) | 101 | |
| chr8:29,317,050–29,317,253 | 3.0 kb | Proximal (<10kb) | 46 | |
| chr8:29,318,868–29,320,832 | at TSS | At TSS | 261 | |
| chr8:29,325,135–29,326,771 | 4.9 kb | Proximal (<10kb) | 16 | |
| chr8:29,328,897–29,329,596 | 8.7 kb | Proximal (<10kb) | 26 | |
| chr8:29,329,962–29,331,910 | 9.7 kb | Proximal (<10kb) | 99 |
Genomic view of the ENSG00000288735 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.