Transcription factors with Perturb-seq knockdown data for ENSG00000288700. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288700 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288700, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:134,250,095–134,251,199 | 235.0 kb | Distal (>10kb) Multiome | 719 | |
| chr3:134,308,427–134,308,921 | 177.1 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr3:134,312,827–134,313,997 | 172.3 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr3:134,363,600–134,365,141 | 121.5 kb | Distal (>10kb) Multiome | 492 | |
| chr3:134,372,925–134,375,830 | 112.3 kb | Distal (>10kb) Multiome | 1010 | |
| chr3:134,406,305–134,407,815 | 79.0 kb | Distal (>10kb) Multiome | 295 | |
| chr3:134,485,113–134,486,743 | 327 bp | At TSS Multiome | 1009 | |
| chr3:134,650,423–134,651,401 | 165.2 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the ENSG00000288700 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.