Transcription factors with Perturb-seq knockdown data for ENSG00000287914. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287914 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287914, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:152,091,982–152,092,342 | 1.7 kb | Proximal (<10kb) | 81 | |
| chr6:152,093,336–152,094,382 | at TSS | At TSS | 107 | |
| chr6:152,096,741–152,097,124 | 2.7 kb | Proximal (<10kb) | 78 | |
| chr6:152,097,679–152,098,057 | 3.7 kb | Proximal (<10kb) | 27 | |
| chr6:152,100,010–152,100,554 | 6.0 kb | Proximal (<10kb) | 154 |
Genomic view of the ENSG00000287914 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.