Transcription factors with Perturb-seq knockdown data for ENSG00000287860. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287860 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287860, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,901,511–6,903,145 | 202.1 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,995,280–6,995,919 | 108.8 kb | Distal (>10kb) Multiome HiCAR | 100 | |
| chr7:7,098,427–7,099,151 | 5.3 kb | Proximal (<10kb) | 57 | |
| chr7:7,099,297–7,099,939 | 4.8 kb | Proximal (<10kb) Multiome | 535 | |
| chr7:7,100,140–7,101,112 | 3.8 kb | Proximal (<10kb) Multiome | 318 | |
| chr7:7,103,460–7,103,648 | 833 bp | At TSS | 158 | |
| chr7:7,104,423–7,104,623 | at TSS | At TSS | 160 | |
| chr7:7,181,606–7,183,506 | 78.1 kb | Distal (>10kb) Multiome | 995 | |
| chr7:7,415,971–7,416,912 | 311.8 kb | Distal (>10kb) Multiome HiCAR | 282 |
Genomic view of the ENSG00000287860 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.