Transcription factors with Perturb-seq knockdown data for ENSG00000287843. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287843 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287843, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:23,819,272–23,820,091 | 6.4 kb | Proximal (<10kb) | 54 | |
| chr9:23,820,523–23,823,516 | 3.0 kb | Proximal (<10kb) | 435 | |
| chr9:23,824,327–23,825,607 | 882 bp | At TSS | 281 | |
| chr9:23,825,805–23,826,813 | at TSS | At TSS | 399 | |
| chr9:23,829,710–23,830,388 | 3.2 kb | Proximal (<10kb) | 135 | |
| chr9:23,831,041–23,832,185 | 4.6 kb | Proximal (<10kb) | 207 |
Genomic view of the ENSG00000287843 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.