Transcription factors with Perturb-seq knockdown data for ENSG00000287697. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287697 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287697, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:174,799,347–174,800,510 | 199.9 kb | Distal (>10kb) Multiome HiCAR | 456 | |
| chr1:174,882,897–174,883,845 | 116.2 kb | Distal (>10kb) Multiome HiCAR | 184 | |
| chr1:174,976,347–174,977,217 | 22.9 kb | Distal (>10kb) Multiome | 181 | |
| chr1:174,998,565–175,000,705 | 166 bp | At TSS Multiome | 1242 | |
| chr1:175,022,930–175,024,023 | 23.9 kb | Distal (>10kb) Multiome | 878 | |
| chr1:175,029,423–175,030,223 | 30.3 kb | Distal (>10kb) Multiome | 562 | |
| chr1:175,129,648–175,130,843 | 130.6 kb | Distal (>10kb) Multiome | 246 | |
| chr1:175,154,371–175,155,390 | 155.4 kb | Distal (>10kb) Multiome | 333 | |
| chr1:175,191,731–175,193,773 | 193.3 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the ENSG00000287697 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.