Transcription factors with Perturb-seq knockdown data for ENSG00000287562. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287562 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287562, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:44,002,061–44,003,708 | 92.7 kb | Distal (>10kb) Multiome | 581 | |
| chr6:44,126,767–44,128,943 | 31.9 kb | Distal (>10kb) Multiome | 845 | |
| chr6:44,151,741–44,152,312 | 56.4 kb | Distal (>10kb) Multiome HiCAR | 575 | |
| chr6:44,202,490–44,203,242 | 107.3 kb | Distal (>10kb) Multiome | 229 | |
| chr6:44,216,763–44,217,285 | 121.4 kb | Distal (>10kb) Multiome | 139 | |
| chr6:44,218,945–44,220,120 | 124.0 kb | Distal (>10kb) Multiome | 799 | |
| chr6:44,223,166–44,224,465 | 128.1 kb | Distal (>10kb) Multiome | 783 | |
| chr6:44,237,380–44,238,386 | 142.3 kb | Distal (>10kb) Multiome | 969 | |
| chr6:44,245,610–44,248,192 | 150.8 kb | Distal (>10kb) Multiome | 1271 | |
| chr6:44,256,209–44,258,064 | 161.8 kb | Distal (>10kb) Multiome HiCAR | 1042 | |
| chr6:44,264,892–44,265,788 | 170.0 kb | Distal (>10kb) Multiome | 760 | |
| chr6:44,270,373–44,271,349 | 175.4 kb | Distal (>10kb) Multiome | 166 | |
| chr6:44,275,626–44,276,572 | 180.4 kb | Distal (>10kb) Multiome | 330 | |
| chr6:44,297,234–44,298,035 | 202.1 kb | Distal (>10kb) Multiome | 356 | |
| chr6:44,312,866–44,313,523 | 217.7 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:44,342,481–44,342,962 | 247.1 kb | Distal (>10kb) Multiome | 133 | |
| chr6:44,387,185–44,388,395 | 292.1 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the ENSG00000287562 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.