Transcription factors with Perturb-seq knockdown data for ENSG00000287492. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287492 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287492, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:48,259,114–48,259,643 | 6.0 kb | Proximal (<10kb) | 36 | |
| chr14:48,259,871–48,260,260 | 5.3 kb | Proximal (<10kb) | 5 | |
| chr14:48,262,314–48,263,007 | 2.6 kb | Proximal (<10kb) | 6 | |
| chr14:48,263,163–48,263,518 | 2.1 kb | Proximal (<10kb) | 3 | |
| chr14:48,266,109–48,266,624 | 789 bp | At TSS Multiome | 98 | |
| chr14:48,267,715–48,268,581 | 2.4 kb | Proximal (<10kb) Multiome | 89 |
Genomic view of the ENSG00000287492 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.