Transcription factors with Perturb-seq knockdown data for ENSG00000287424. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287424 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287424, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:165,748,226–165,749,065 | 8.6 kb | Proximal (<10kb) | 115 | |
| chr4:165,751,176–165,752,149 | 5.5 kb | Proximal (<10kb) | 36 | |
| chr4:165,757,363–165,757,715 | at TSS | At TSS | 31 | |
| chr4:165,757,821–165,757,929 | 161 bp | At TSS | 7 | |
| chr4:165,766,864–165,767,231 | 9.2 kb | Proximal (<10kb) | 10 |
Genomic view of the ENSG00000287424 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.