Transcription factors with Perturb-seq knockdown data for ENSG00000287378. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287378 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287378, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:100,249,838–100,250,330 | 9.9 kb | Proximal (<10kb) | 6 | |
| chr3:100,254,235–100,254,464 | 5.8 kb | Proximal (<10kb) | 244 | |
| chr3:100,260,138–100,261,732 | 607 bp | At TSS Multiome | 908 | |
| chr3:100,263,026–100,263,491 | 2.8 kb | Proximal (<10kb) | 51 | |
| chr3:100,334,205–100,335,290 | 74.4 kb | Distal (>10kb) Multiome | 849 | |
| chr3:100,400,431–100,402,077 | 141.1 kb | Distal (>10kb) Multiome | 977 | |
| chr3:100,491,845–100,493,045 | 232.2 kb | Distal (>10kb) Multiome | 816 |
Genomic view of the ENSG00000287378 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.