Transcription factors with Perturb-seq knockdown data for ENSG00000287156. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287156 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287156, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:53,946,269–53,947,266 | 7.4 kb | Proximal (<10kb) | 247 | |
| chr14:53,951,617–53,954,877 | at TSS | At TSS | 646 | |
| chr14:53,954,985–53,955,145 | 315 bp | At TSS | 175 | |
| chr14:53,955,635–53,957,282 | 965 bp | At TSS | 747 | |
| chr14:53,963,452–53,964,181 | 8.8 kb | Proximal (<10kb) | 208 | |
| chr14:53,964,297–53,964,485 | 9.6 kb | Proximal (<10kb) | 19 |
Genomic view of the ENSG00000287156 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.