Transcription factors with Perturb-seq knockdown data for ENSG00000287127. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287127 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287127, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:66,176,683–66,178,388 | 255.0 kb | Distal (>10kb) Multiome | 818 | |
| chr8:66,228,525–66,229,416 | 203.4 kb | Distal (>10kb) Multiome | 92 | |
| chr8:66,348,361–66,349,034 | 83.7 kb | Distal (>10kb) Multiome | 176 | |
| chr8:66,428,113–66,430,401 | 3.6 kb | Proximal (<10kb) Multiome | 921 | |
| chr8:66,431,895–66,432,840 | 132 bp | At TSS Multiome | 609 | |
| chr8:66,436,175–66,436,416 | 3.8 kb | Proximal (<10kb) | 21 | |
| chr8:66,438,980–66,439,800 | 6.9 kb | Proximal (<10kb) Multiome | 484 | |
| chr8:66,512,582–66,513,139 | 80.5 kb | Distal (>10kb) Multiome | 239 | |
| chr8:66,612,352–66,614,219 | 181.0 kb | Distal (>10kb) Multiome HiCAR | 862 | |
| chr8:66,666,261–66,667,884 | 235.0 kb | Distal (>10kb) Multiome | 889 | |
| chr8:66,712,294–66,713,281 | 280.4 kb | Distal (>10kb) Multiome | 648 |
Genomic view of the ENSG00000287127 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.