Transcription factors with Perturb-seq knockdown data for ENSG00000287044. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287044 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287044, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:108,260,173–108,261,671 | 297.1 kb | Distal (>10kb) Multiome | 970 | |
| chr6:108,294,541–108,295,678 | 263.3 kb | Distal (>10kb) Multiome | 880 | |
| chr6:108,557,184–108,561,557 | 2.6 kb | Proximal (<10kb) Multiome | 1119 | |
| chr6:108,561,776–108,563,199 | 4.5 kb | Proximal (<10kb) Multiome | 782 | |
| chr6:108,838,106–108,838,816 | 280.1 kb | Distal (>10kb) Multiome HiCAR | 212 | |
| chr6:108,847,848–108,848,955 | 290.2 kb | Distal (>10kb) Multiome HiCAR | 734 |
Genomic view of the ENSG00000287044 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.