Transcription factors with Perturb-seq knockdown data for ENSG00000287031. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287031 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287031, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:6,377,871–6,379,073 | 69 bp | At TSS Multiome | 776 | |
| chr5:6,381,030–6,381,446 | 2.4 kb | Proximal (<10kb) | 4 | |
| chr5:6,475,554–6,476,306 | 97.2 kb | Distal (>10kb) Multiome | 93 | |
| chr5:6,582,577–6,583,754 | 204.5 kb | Distal (>10kb) Multiome | 244 | |
| chr5:6,632,465–6,634,316 | 254.6 kb | Distal (>10kb) Multiome | 837 |
Genomic view of the ENSG00000287031 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.