Transcription factors with Perturb-seq knockdown data for ENSG00000287021. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287021 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287021, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:127,513,794–127,515,756 | 109.5 kb | Distal (>10kb) Multiome | 157 | |
| chr4:127,622,432–127,623,976 | 714 bp | At TSS Multiome | 465 | |
| chr4:127,632,393–127,633,532 | 9.1 kb | Proximal (<10kb) Multiome | 537 | |
| chr4:127,772,776–127,773,663 | 149.4 kb | Distal (>10kb) Multiome | 169 | |
| chr4:127,781,184–127,783,476 | 158.4 kb | Distal (>10kb) Multiome | 938 | |
| chr4:127,845,791–127,846,800 | 222.5 kb | Distal (>10kb) Multiome | 146 | |
| chr4:127,880,303–127,882,032 | 257.4 kb | Distal (>10kb) Multiome | 933 |
Genomic view of the ENSG00000287021 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.