Transcription factors with Perturb-seq knockdown data for ENSG00000286985. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286985 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286985, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:11,346,754–11,348,253 | 285.5 kb | Distal (>10kb) Multiome | 547 | |
| chr8:11,439,886–11,440,775 | 192.8 kb | Distal (>10kb) Multiome | 160 | |
| chr8:11,466,250–11,468,072 | 165.4 kb | Distal (>10kb) Multiome | 594 | |
| chr8:11,563,746–11,564,943 | 68.4 kb | Distal (>10kb) Multiome | 644 | |
| chr8:11,617,248–11,618,158 | 15.3 kb | Distal (>10kb) Multiome | 126 | |
| chr8:11,631,573–11,631,843 | 1.3 kb | Proximal (<10kb) | 198 | |
| chr8:11,632,784–11,633,414 | 9 bp | At TSS Multiome | 233 | |
| chr8:11,642,077–11,643,101 | 9.5 kb | Proximal (<10kb) Multiome | 247 | |
| chr8:11,660,832–11,661,535 | 28.1 kb | Distal (>10kb) Multiome | 21 | |
| chr8:11,682,733–11,683,887 | 50.1 kb | Distal (>10kb) Multiome | 157 | |
| chr8:11,702,714–11,704,461 | 70.0 kb | Distal (>10kb) Multiome | 687 | |
| chr8:11,708,271–11,710,646 | 77.1 kb | Distal (>10kb) Multiome | 246 | |
| chr8:11,736,329–11,736,895 | 103.5 kb | Distal (>10kb) Multiome | 615 | |
| chr8:11,743,316–11,744,611 | 111.2 kb | Distal (>10kb) Multiome | 243 | |
| chr8:11,769,172–11,770,442 | 136.6 kb | Distal (>10kb) Multiome | 764 | |
| chr8:11,801,766–11,803,423 | 169.5 kb | Distal (>10kb) Multiome | 901 | |
| chr8:11,807,986–11,809,046 | 175.3 kb | Distal (>10kb) Multiome | 514 | |
| chr8:11,867,298–11,868,997 | 235.0 kb | Distal (>10kb) Multiome | 752 | |
| chr8:11,902,256–11,902,767 | 269.4 kb | Distal (>10kb) Multiome | 604 |
Genomic view of the ENSG00000286985 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.