Transcription factors with Perturb-seq knockdown data for ENSG00000286964. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286964 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286964, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:134,914,755–134,915,732 | 122.0 kb | Distal (>10kb) Multiome | 575 | |
| chrX:135,003,873–135,004,623 | 33.1 kb | Distal (>10kb) Multiome | 369 | |
| chrX:135,022,346–135,022,840 | 14.8 kb | Distal (>10kb) Multiome | 290 | |
| chrX:135,030,460–135,030,822 | 6.5 kb | Proximal (<10kb) | 29 | |
| chrX:135,031,918–135,032,932 | 5.0 kb | Proximal (<10kb) Multiome | 428 | |
| chrX:135,051,315–135,052,574 | 14.9 kb | Distal (>10kb) Multiome | 523 | |
| chrX:135,097,570–135,099,197 | 61.6 kb | Distal (>10kb) Multiome | 354 |
Genomic view of the ENSG00000286964 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.