Transcription factors with Perturb-seq knockdown data for ENSG00000286904. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286904 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286904, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:111,883,652–111,884,536 | 171.2 kb | Distal (>10kb) Multiome HiCAR | 911 | |
| chr2:111,897,537–111,899,424 | 156.9 kb | Distal (>10kb) Multiome HiCAR | 926 | |
| chr2:112,047,188–112,048,562 | 7.5 kb | Proximal (<10kb) Multiome | 275 | |
| chr2:112,048,672–112,049,071 | 6.3 kb | Proximal (<10kb) | 134 | |
| chr2:112,049,328–112,049,683 | 5.7 kb | Proximal (<10kb) | 128 | |
| chr2:112,053,884–112,054,856 | 518 bp | At TSS Multiome | 492 | |
| chr2:112,054,956–112,056,432 | at TSS | At TSS | 968 | |
| chr2:112,181,502–112,182,275 | 126.5 kb | Distal (>10kb) Multiome | 174 | |
| chr2:112,254,532–112,255,517 | 199.7 kb | Distal (>10kb) Multiome | 915 | |
| chr2:112,275,156–112,276,567 | 220.9 kb | Distal (>10kb) Multiome | 1201 | |
| chr2:112,541,785–112,542,849 | 486.9 kb | Distal (>10kb) Multiome HiCAR | 1070 |
Genomic view of the ENSG00000286904 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.