Transcription factors with Perturb-seq knockdown data for ENSG00000286881. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286881 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286881, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:21,515,560–21,517,745 | 8.8 kb | Proximal (<10kb) | 690 | |
| chr10:21,518,097–21,518,552 | 8.0 kb | Proximal (<10kb) | 246 | |
| chr10:21,520,150–21,520,286 | 6.3 kb | Proximal (<10kb) | 129 | |
| chr10:21,523,007–21,524,077 | 2.5 kb | Proximal (<10kb) | 224 | |
| chr10:21,524,213–21,526,810 | at TSS | At TSS | 1100 | |
| chr10:21,527,043–21,527,629 | 476 bp | At TSS | 673 | |
| chr10:21,533,309–21,535,662 | 6.7 kb | Proximal (<10kb) | 1089 |
Genomic view of the ENSG00000286881 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.