Transcription factors with Perturb-seq knockdown data for ENSG00000286833. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286833 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286833, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:132,304,630–132,305,296 | 42.6 kb | Distal (>10kb) Multiome | 133 | |
| chr2:132,346,971–132,347,801 | at TSS | At TSS | 196 | |
| chr2:132,349,207–132,349,364 | 1.7 kb | Proximal (<10kb) | 12 | |
| chr2:132,352,429–132,353,438 | 5.2 kb | Proximal (<10kb) Multiome | 115 | |
| chr2:132,391,950–132,392,884 | 44.9 kb | Distal (>10kb) Multiome | 159 | |
| chr2:132,402,879–132,404,615 | 56.9 kb | Distal (>10kb) Multiome | 204 | |
| chr2:132,415,626–132,417,484 | 69.1 kb | Distal (>10kb) Multiome HiCAR | 784 | |
| chr2:132,543,726–132,544,708 | 196.7 kb | Distal (>10kb) Multiome | 107 |
Genomic view of the ENSG00000286833 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.