Transcription factors with Perturb-seq knockdown data for ENSG00000286782. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286782 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286782, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,957,639–34,958,516 | 58.0 kb | Distal (>10kb) Multiome | 211 | |
| chr9:34,988,494–34,990,699 | 26.5 kb | Distal (>10kb) Multiome | 703 | |
| chr9:35,006,194–35,006,530 | 9.5 kb | Proximal (<10kb) | 4 | |
| chr9:35,023,548–35,023,746 | 7.5 kb | Proximal (<10kb) | 62 | |
| chr9:35,024,811–35,025,108 | 8.7 kb | Proximal (<10kb) | 5 | |
| chr9:35,026,200–35,027,109 | 10.8 kb | Distal (>10kb) Multiome | 187 | |
| chr9:35,071,688–35,073,229 | 56.0 kb | Distal (>10kb) Multiome | 975 | |
| chr9:35,079,435–35,080,247 | 63.9 kb | Distal (>10kb) Multiome | 773 | |
| chr9:35,095,921–35,096,910 | 80.4 kb | Distal (>10kb) Multiome | 960 | |
| chr9:35,102,684–35,103,800 | 87.2 kb | Distal (>10kb) Multiome | 886 | |
| chr9:35,110,953–35,112,122 | 95.6 kb | Distal (>10kb) Multiome | 527 | |
| chr9:35,113,899–35,117,460 | 101.2 kb | Distal (>10kb) Multiome | 840 | |
| chr9:35,161,521–35,162,743 | 145.9 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the ENSG00000286782 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.