Transcription factors with Perturb-seq knockdown data for ENSG00000286753. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286753 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286753, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:5,139,356–5,140,841 | 281.9 kb | Distal (>10kb) Multiome HiCAR | 364 | |
| chr5:5,179,195–5,180,337 | 242.4 kb | Distal (>10kb) Multiome | 139 | |
| chr5:5,182,894–5,183,828 | 238.7 kb | Distal (>10kb) Multiome | 303 | |
| chr5:5,270,819–5,272,461 | 150.7 kb | Distal (>10kb) Multiome | 448 | |
| chr5:5,419,263–5,419,639 | 2.5 kb | Proximal (<10kb) | 120 | |
| chr5:5,421,006–5,423,420 | 305 bp | At TSS Multiome | 913 | |
| chr5:5,429,028–5,429,534 | 6.9 kb | Proximal (<10kb) | 15 | |
| chr5:5,494,413–5,495,371 | 72.7 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the ENSG00000286753 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.