Transcription factors with Perturb-seq knockdown data for ENSG00000286742. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286742 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286742, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:92,424,381–92,424,856 | 228.7 kb | Distal (>10kb) Multiome | 634 | |
| chr7:92,447,026–92,448,601 | 205.8 kb | Distal (>10kb) Multiome | 973 | |
| chr7:92,527,585–92,529,221 | 124.7 kb | Distal (>10kb) Multiome | 921 | |
| chr7:92,589,648–92,590,940 | 63.1 kb | Distal (>10kb) Multiome | 1025 | |
| chr7:92,608,546–92,609,216 | 44.5 kb | Distal (>10kb) Multiome | 301 | |
| chr7:92,653,200–92,653,443 | at TSS | At TSS | 31 | |
| chr7:92,763,629–92,764,462 | 110.6 kb | Distal (>10kb) Multiome | 433 | |
| chr7:92,832,617–92,837,194 | 179.8 kb | Distal (>10kb) Multiome | 1121 | |
| chr7:92,925,995–92,927,027 | 273.2 kb | Distal (>10kb) Multiome | 201 |
Genomic view of the ENSG00000286742 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.