Transcription factors with Perturb-seq knockdown data for ENSG00000286724. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286724 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286724, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:18,763,106–18,763,616 | 221.1 kb | Distal (>10kb) Multiome | 23 | |
| chrX:18,983,791–18,985,149 | 258 bp | At TSS Multiome | 698 | |
| chrX:19,121,907–19,123,002 | 138.0 kb | Distal (>10kb) Multiome | 175 | |
| chrX:19,343,580–19,344,754 | 359.4 kb | Distal (>10kb) Multiome HiCAR | 591 |
Genomic view of the ENSG00000286724 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.