Transcription factors with Perturb-seq knockdown data for ENSG00000286717. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286717 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286717, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:37,220,678–37,221,494 | 372.8 kb | Distal (>10kb) Multiome HiCAR | 881 | |
| chr21:37,365,724–37,368,330 | 227.5 kb | Distal (>10kb) Multiome | 938 | |
| chr21:37,563,444–37,565,351 | 30.0 kb | Distal (>10kb) Multiome | 839 | |
| chr21:37,590,890–37,591,207 | 2.8 kb | Proximal (<10kb) | 41 | |
| chr21:37,591,941–37,593,603 | 823 bp | At TSS Multiome | 223 | |
| chr21:37,594,045–37,594,755 | 68 bp | At TSS | 42 | |
| chr21:37,600,123–37,600,368 | 6.1 kb | Proximal (<10kb) | 12 |
Genomic view of the ENSG00000286717 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.