Transcription factors with Perturb-seq knockdown data for ENSG00000286707. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286707 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286707, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:26,033,136–26,034,956 | 264.6 kb | Distal (>10kb) Multiome | 1165 | |
| chr2:26,172,352–26,174,365 | 125.6 kb | Distal (>10kb) Multiome | 420 | |
| chr2:26,178,689–26,179,345 | 119.4 kb | Distal (>10kb) Multiome | 245 | |
| chr2:26,179,469–26,180,030 | 118.8 kb | Distal (>10kb) Multiome | 122 | |
| chr2:26,184,159–26,185,510 | 113.7 kb | Distal (>10kb) Multiome | 494 | |
| chr2:26,244,319–26,245,633 | 53.8 kb | Distal (>10kb) Multiome | 928 | |
| chr2:26,345,352–26,346,859 | 47.4 kb | Distal (>10kb) Multiome | 1002 | |
| chr2:26,401,746–26,402,358 | 103.4 kb | Distal (>10kb) Multiome | 231 | |
| chr2:26,503,215–26,503,885 | 205.0 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the ENSG00000286707 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.