Transcription factors with Perturb-seq knockdown data for ENSG00000286693. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286693 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286693, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:35,503,729–35,504,887 | 203.4 kb | Distal (>10kb) Multiome | 165 | |
| chr8:35,641,872–35,643,482 | 65.0 kb | Distal (>10kb) Multiome | 221 | |
| chr8:35,783,273–35,783,804 | 75.9 kb | Distal (>10kb) Multiome | 97 | |
| chr8:35,867,193–35,868,507 | 160.2 kb | Distal (>10kb) Multiome | 239 | |
| chr8:35,873,828–35,874,561 | 166.5 kb | Distal (>10kb) Multiome | 140 |
Genomic view of the ENSG00000286693 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.