Transcription factors with Perturb-seq knockdown data for ENSG00000286622. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286622 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286622, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:9,898,231–9,899,122 | 156.5 kb | Distal (>10kb) Multiome | 137 | |
| chr8:9,903,857–9,904,888 | 150.7 kb | Distal (>10kb) Multiome | 164 | |
| chr8:9,906,366–9,907,146 | 148.2 kb | Distal (>10kb) Multiome | 253 | |
| chr8:10,054,019–10,055,820 | 306 bp | At TSS Multiome | 761 | |
| chr8:10,334,318–10,335,970 | 279.8 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the ENSG00000286622 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.