Transcription factors with Perturb-seq knockdown data for ENSG00000286351. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286351 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286351, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:58,919,255–58,920,781 | 181.6 kb | Distal (>10kb) Multiome HiCAR | 754 | |
| chr12:58,922,716–58,924,329 | 178.8 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr12:58,924,758–58,926,054 | 176.8 kb | Distal (>10kb) Multiome HiCAR | 329 | |
| chr12:58,949,852–58,950,996 | 151.6 kb | Distal (>10kb) Multiome | 153 | |
| chr12:59,074,983–59,076,039 | 26.6 kb | Distal (>10kb) Multiome | 168 | |
| chr12:59,103,407–59,103,740 | 1.3 kb | Proximal (<10kb) | 3 | |
| chr12:59,108,609–59,108,863 | 6.5 kb | Proximal (<10kb) | 3 | |
| chr12:59,368,115–59,368,972 | 266.4 kb | Distal (>10kb) Multiome | 162 |
Genomic view of the ENSG00000286351 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.