Transcription factors with Perturb-seq knockdown data for ENSG00000286334. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286334 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286334, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:97,109,602–97,110,401 | 185.3 kb | Distal (>10kb) Multiome | 639 | |
| chr13:97,226,862–97,227,846 | 68.1 kb | Distal (>10kb) Multiome | 390 | |
| chr13:97,432,559–97,435,046 | 137.8 kb | Distal (>10kb) Multiome | 900 |
Genomic view of the ENSG00000286334 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.