Transcription factors with Perturb-seq knockdown data for ENSG00000286277. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286277 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286277, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:14,210,686–14,212,342 | 220.4 kb | Distal (>10kb) Multiome | 895 | |
| chr6:14,296,854–14,297,404 | 134.6 kb | Distal (>10kb) Multiome | 23 | |
| chr6:14,383,618–14,384,936 | 47.3 kb | Distal (>10kb) Multiome | 174 | |
| chr6:14,544,040–14,544,995 | 112.9 kb | Distal (>10kb) Multiome | 137 | |
| chr6:14,639,740–14,640,854 | 208.6 kb | Distal (>10kb) Multiome | 287 | |
| chr6:15,409,286–15,410,423 | 978.0 kb | Distal (>10kb) Multiome HiCAR | 247 |
Genomic view of the ENSG00000286277 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.