Transcription factors with Perturb-seq knockdown data for ENSG00000286271. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286271 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286271, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:42,756,638–42,757,621 | 57.0 kb | Distal (>10kb) Multiome | 314 | |
| chr5:42,811,575–42,812,593 | 1.7 kb | Proximal (<10kb) Multiome | 702 | |
| chr5:42,813,381–42,813,999 | at TSS | At TSS | 122 | |
| chr5:42,908,461–42,909,511 | 95.2 kb | Distal (>10kb) Multiome | 451 | |
| chr5:43,016,201–43,016,848 | 202.6 kb | Distal (>10kb) Multiome | 194 | |
| chr5:43,017,299–43,018,875 | 204.3 kb | Distal (>10kb) Multiome | 870 | |
| chr5:43,041,652–43,043,529 | 228.4 kb | Distal (>10kb) Multiome | 897 | |
| chr5:43,064,252–43,065,217 | 251.1 kb | Distal (>10kb) Multiome | 959 | |
| chr5:43,065,881–43,067,664 | 252.8 kb | Distal (>10kb) Multiome | 928 | |
| chr5:43,105,415–43,106,204 | 292.0 kb | Distal (>10kb) Multiome | 820 |
Genomic view of the ENSG00000286271 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.